Stauroneis akamina belongs to a group of medium to large Stauroneis species with oblong areolae that are often irregularly spaced. It differs from S. nobilis by its smooth valve outline and smaller size. Stauroneis alabamae is larger and has a lower stria density. Stauroneis margaritorae is shorter (60-90 µm) with narrower valves (13-16 µm). Stauroneis nobilis var. minima has smaller valves with narrower apices. Stauroneis baconiana has linear valves that are much narrower.